Quadruple Marker Test- Purpose, Risks, Treatment and Results

Quadruple Marker Test: Unveiling Insights for a Healthier Tomorrow

The Quadruple Marker Test, also known as the Quad Marker or Quad Screen, is a prenatal screening test designed to provide valuable insights into the health of both the fetus and the expecting mother. This comprehensive test is typically performed between the 15th and 20th weeks of pregnancy and assesses specific markers to identify potential risks and conditions.

The primary purpose of the Quadruple Marker Test is to assess the risk of certain chromosomal abnormalities and neural tube defects in the developing fetus. The test evaluates four specific markers:

Alpha-fetoprotein (AFP): Produced by the fetal liver, AFP levels are measured to assess the risk of neural tube defects, such as spina bifida.

Human Chorionic Gonadotropin (hCG): This hormone is crucial for maintaining pregnancy and abnormal levels may indicate chromosomal abnormalities.

Estriol: Produced by both the fetus and the placenta, low estriol levels may suggest potential chromosomal abnormalities.

Inhibin-A: Elevated levels of inhibin-A can be associated with an increased risk of Down syndrome.

Quadruple Marker Test Time
In pregnancy, a quadruple marker test is performed during the second trimester which ideally means sometime between 15 weeks and 20 weeks of pregnancy. If an individual has any of the following risk factors, the doctor might recommend them to go for a quadruple marker test:

  1. Is above the age of 35 or older when the baby is due.
  2. Has had a viral infection during pregnancy.
  3. Has a family history of birth defects or congenital disabilities.
  4. Is diagnosed with type 1 diabetes during pregnancy.
  5. On harmful medication during pregnancy.
  6. Has been exposed to high levels of radiation.

It’s important to note that the Quadruple Marker Test is a screening test, not a diagnostic one. While it provides valuable information, it does not guarantee a definitive diagnosis. False positives and false negatives are possible, necessitating further diagnostic tests for confirmation.

The Quadruple Marker Test itself does not offer treatment; instead, it serves as an informative tool to identify potential risks. In the case of abnormal results, healthcare providers may recommend additional tests such as amniocentesis or chorionic villus sampling (CVS) for a more accurate diagnosis. These diagnostic tests can provide detailed information about the fetus’s chromosomal makeup.

Interpreting the results requires the expertise of healthcare professionals. Normal results indicate a lower likelihood of the assessed conditions, providing reassurance to the expecting parents. Abnormal results, however, may prompt further testing and discussions about potential courses of action.


the Quadruple Marker Test is a valuable tool in prenatal care, offering insights that can guide healthcare decisions for both the mother and the developing fetus. Expecting parents are encouraged to consult with their healthcare providers to understand the implications of the results and make informed decisions regarding their pregnancy journey.

Navigate the path to parenthood with confidence at DMS Diagnostics! Our Quadruple Marker Test unravels the intricacies of prenatal health, providing a thorough understanding of potential risks and conditions. With precision and care, we guide you through the purpose, risks, treatments, and results, ensuring a journey to parenthood rooted in knowledge and support.

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